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Malnutrition-Linked Diabetes as 'Type 5,' Highlighting Overlooked Global Health Crisis**

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Malnutrition-Linked Diabetes as 'Type 5,' Highlighting Overlooked Global Health Crisis**

 

**LONDON** – In a significant move addressing a long-underrecognized global health issue, the International Diabetes Federation (IDF) has formally classified a distinct form of diabetes, primarily linked to malnutrition, often referred to as "Type 5 Diabetes." This designation, confirmed during the IDF World Diabetes Congress in Bangkok, Thailand, in April 2024, brings official recognition to a condition predominantly affecting young, underweight individuals in developing nations, differentiating it starkly from the more widely known Type 1 and Type 2 diabetes.

Malnutrition-Linked Diabetes as 'Type 5,' Highlighting Overlooked Global Health Crisis**
Malnutrition-Linked Diabetes as 'Type 5,' Highlighting Overlooked Global Health Crisis**



Malnutrition-Linked Diabetes as 'Type 5,' Highlighting Overlooked Global Health Crisis**


 

This newly classified condition

sometimes also associated with the term "Maturity-Onset Diabetes of the Young (MODY)" in the source text – though traditionally MODY refers to specific genetic forms – is characterized by impaired insulin production stemming not from autoimmune attack (like Type 1) or insulin resistance linked to obesity (like Type 2), but from severe nutritional deficiencies impacting pancreatic beta-cell function.

  •  The source material also describes a rare, inherited component involving a
  •  specific gene mutation passed down from a parent, potentially leading to a
  •  50% chance of inheritance in offspring, further complicating the
  •  nomenclature but underscoring its unique etiology distinct from lifestyle-
  • related diabetes.

 

Dr. Meredith Hawkins

Professor of Medicine at Albert Einstein College of Medicine and founder of the Einstein Global Diabetes Institute, highlighted the historical neglect of this condition. "For years, malnutrition-related diabetes has been significantly underdiagnosed and poorly understood," she stated, emphasizing that the IDF's designation "represents a critical step toward raising awareness of a health problem causing devastating harm to a large number of people."

 

Malnutrition-Linked Diabetes as 'Type 5,' Highlighting Overlooked Global Health Crisis**

  1. First observed clinically in Jamaica as early as 1955, this form of diabetes
  2.  was briefly classified by the World Health Organization (WHO) as
  3.  "malnutrition-related diabetes" in the 1980s. However, this classification was
  4.  rescinded in 1999 due to a perceived lack of robust scientific evidence at the
  5.  time. This left millions suffering from a condition that defied conventional
  6.  diabetes categorizations. Patients were typically young and thin

 suggesting Type 1, yet standard insulin therapy often proved ineffective or dangerously led to severe hypoglycemia (low blood sugar), sometimes with fatal consequences. They also did not fit the profile for Type 2, which is commonly associated with obesity.

 

Research spearheaded by Dr. Hawkins

 and collaborators, including work with the Christian Medical College in India, was pivotal in unraveling the distinct pathophysiology. Their studies, culminating in findings published around 2022, demonstrated that individuals with this condition exhibit a profound defect in insulin secretion, a mechanism fundamentally different from both Type 1 and Type 2 diabetes. Dr. Nihal Thomas, Professor of Endocrinology at Christian Medical College and a member of the Type 5 Diabetes Task Force, noted that the lack of official recognition hampered research and led to misdiagnosis.

 

  • The scale of the problem is considerable. Estimates suggest that this form of
  •  diabetes affects approximately 25 million people globally, with a heavy
  •  concentration in Asia and Africa. Affected individuals often present with a
  •  low Body Mass Index (BMI), frequently below 19 kg/m². Dr. Hawkins has
  •  strikingly compared its prevalence to major infectious diseases, stating it is
  •  "more common than tuberculosis and nearly as prevalent as HIV/AIDS,"
  •  underscoring the urgency of addressing this hidden epidemic.

 

The formal recognition by the IDF

 is expected to catalyze much-needed research into effective diagnostic tools and treatment protocols. Currently, optimal management strategies remain unclear. While the source suggests exploring diets higher in protein and lower in carbohydrates.

  1.  alongside careful attention to micronutrient status (vitamins and minerals),
  2.  these approaches require rigorous investigation. The grim reality, as noted by
  3.  Dr. Hawkins, is that without appropriate understanding and treatment, life
  4.  expectancy after diagnosis can be distressingly short.

 

The designation of Type 5 Diabetes

 marks a turning point. It provides a formal framework for the global medical community to focus resources, conduct targeted research, develop specific treatment guidelines, and ultimately improve the lives of millions affected by this debilitating condition.

 which has lingeredin the shadows of global health for far too long. The challenge now lies in translating this recognition into tangible improvements in diagnosis, care, and outcomes worldwide.

Malnutrition-Linked Diabetes as 'Type 5,' Highlighting Overlooked Global Health Crisis**


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Tamer Nabil Moussa

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